Anastrozole Arimidex

using substantial amounts of aromatizing steroids

Anastrozole
Alias: Arimidex
CAS No: 120511-73-1
MF: C17H19N5
MW: 293.37

Melt point: 81-82℃
Purity: 98%
Appearance: white powder.

Applications:
The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids. Arimidex does not have the side effects of aminoglutethimide (Cytadren) and can achieve a high degree of estrogen blockade, much moreso than Cytadren. It is possible to reduce estrogen too much with Arimidex, and for this reason blood tests, or less preferably salivary tests, should be taken after the first week of use to determine if the dosing is correct.
The trial suggested that anastrozole is the preferred medical therapy for postmenopausal women with localized estrogen receptor (ER) positive breast cancer.

Specifications:

ItemsStandardResults
DescriptionWhite crystalline powderComplies
IdentificationIR
HPLC
Reactive
Conform with standard IR
Conform with standard HPLC
Conform
SolubilityFreely soluble in methanol,acetone,ethanol and tetrahydrofuran.And very soluble in acetonitrileComplies
Total Impuritymax.0.5%0.18%
Total Unspecified Impuritymax. 0.2%0.08%
Individual unspecified impurltymax. 0.1%0.05%
Related compound Bmax. 0.2%0.07%
Related compound Cmax. 0.2%0.04%
Related compound Dmax. 0.1%0.05%
Related compound Emax. 0.1%0.06%
Limit of cyclohexanemax. 0.08%ND
Limit of ethylacetatemax. 0.1%0.07%
Melting point81.0~84.0℃82.5~83.2℃
Watermax. 0.3%0.21%
Residue on ignitionmax. 0.1%0.07%
Heavy Metalsmax.0.001%Complies
Assay(HPLC)98.0%~102.0%99.8%
StorageCool and dry
ConclusionIt complies to USP32 .


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